Hypoxic Adaptation | Hugh Montgomery

A talk by Hugh Montgomery from TBS23


A talk by Hugh Montgomery at The Big Sick 2023 conference. Kindly shared with permission.
See the TBS23 landing page for the programme and full set of talks.


The oxygen supply to the body may fall for many reasons. Traditionally, we are taught that the human adaptive response is to ‘increase delivery’ (DO2) by raising haematocrit, and ventilatory/ heart rate, for instance. In critical care, some likewise aim to maintain DO2. Likewise, ‘early feeding’ is considered essential. But were we correctly taught? Should we manage ‘food and fuel’ in a very different way? Is ‘less’ actually ‘more’?


Until we have final edits ready the video below is straight from the livestream. Expect a few audio issues and other glitches here and there.




Professor of Intensive Care Medicine, UCL


Hugh obtained a 1st class BSc (cardiorespiratory Physiology/ Neuropharmacology) in 1984, his medical Degree (1987) and his MDRes in 1997. He completed specialist training in General Internal Medicine/Cardiology/Intensive Care Medicine (ICM), and is now a consultant Intensivist in London, and Professor of Intensive Care Medicine at University College London (UCL) where he also directs the Centre for Human Health and Performance. He has published >550 scientific research articles and has won >8 national and international awards. He is perhaps best known for his discovery (reported in 1998) of ‘the first gene for human fitness’. During the 2020-21 Covid pandemic, he sat on the council of the Uk Intensive Care Society, where he led external relations. He chaired the UK Covid Critical Care Committee. Hugh chaired the two Lancet Commissions on Human Health and Climate Change, and now co-chairs the 35-institition 27-country Lancet Countdown on Health and Climate Change. He has written and lectured extensively on the subject, and has briefed policymakers nationally and internationally, He was appointed to the post of London Leader by Greater London Authority’s Sustainable Development Commission, attended many of the international ‘COP’ negotiations, and led the children’s climate education ‘Project Genie’. He was awarded an OBE in 2022 for his leadership in ICU and also Climate Change.


Email: [email protected]

COI declared


Mads Astvad
 | Website

Scandinavian paediatric anaesthetist / intensivist.
Digital MedEd
Co-founder scanFOAM.org
Co-organiser CphCC & TBS-Zermatt (aka The Big Sick)
Medical lead REPEL (resilience in pediatric emergency life support)
Web dev SSAI.info

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